Table 1.
Combination index (CI) values calculated for each combined drug treatments in PLC/PRF/5 and HepG2 cells. Each value was derived from the method described by Chou and Talalay and implemented in CompuSyn software. R = Regorafenib; CGA = Chlorogenic Acid.
| PLC/PRF/5 | HepG2 | ||||
|---|---|---|---|---|---|
| R (µM) | CGA (µM) | CI | R (µM) | CGA (µM) | CI |
| 1 | 100 | 0.50 | 0.1 | 100 | 0.82 |
| 1 | 200 | 0.58 | 0.1 | 200 | 0.39 |
| 1 | 400 | 0.39 | 0.1 | 400 | 0.20 |
| 2.5 | 100 | 0.86 | 0.5 | 100 | 0.63 |
| 2.5 | 200 | 0.76 | 0.5 | 200 | 0.49 |
| 2.5 | 400 | 0.22 | 0.5 | 400 | 0.15 |
| 5 | 100 | 0.65 | 1 | 100 | 0.42 |
| 5 | 200 | 0.43 | 1 | 200 | 0.23 |
| 5 | 400 | 0.18 | 1 | 400 | 0.07 |