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. 2018 May 2;19(5):1339. doi: 10.3390/ijms19051339

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of somatotropic hormone supplementation in liver. (A) Representative histological images of livers from experimental groups after 22 weeks of feeding with either chow, high fat diet (HFD) and HFD supplemented with growth hormone GH or insulin-like growth factor-1 (IGF-1). (B) Quantification of liver steatosis by histology in percentage of steatotic hepatocytes in experimental groups. No significant increase in steatosis can be observed in HFD + IGF-1 group compared to Chow. (C) Histology Score. No significant changes were observed in liver inflammation, ballooning and fibrosis in histology. (D) Hepatic triglycerides content according to experimental groups. A significant reduction of triglycerides content was observed in HFD + GH group. (E) Effects of hormone supplementation in lipogenic gene expression. A significant reduction was observed in HFD + GH group compared to HFD. (F) Serum ALT levels according to experimental groups. A significant reduction was observed in HFD + GH and HFD + IGF-1 groups compared to HFD. * p < 0.05; ** p < 0.01.