Table 2.
Inhibition-% of violacein production by the highly active compounds at 40 µM and IC50 values of the leads with 95% confidence intervals. Results are reported as mean ± standard deviation (SD) of three independent tests. N/A = not applicable, N.A. = not analyzed, Que = quercetin. The IUPAC names of the compounds are listed in Table S4.
| Compound | Class | Inhibition-% 1 | IC50 (µM) | 95% Confidence Intervals |
|---|---|---|---|---|
| 144 | Nucleoside analogue | 0 ± 5.2 | N.A. | |
| 339 | N/A | 3.7 ± 1.8 | N.A. | |
| 341 | Flavonoid (isoflavonoid) | 26.9 ± 7.7 | N.A. | |
| 575 | Flavonoid (flavonol) | 60.9 ± 4.1 | N.A. | |
| 916 | Flavonoid (flavone) | 35.8 ± 1.1 | N.A. | |
| 1698 | Lignan | 2.6 ± 4.6 | N.A. | |
| 2117 | Flavonoid (flavone) | 99.7 ± 1.0 | 9.6 | 7.9–11.8 |
| 2307 | Alkaloid | 76.1 ± 3.3 | N.A. | |
| 2896 | Flavonoid (flavone) | 83.5 ± 1.4 | 13.9 | 8.5–22.5 |
| Que | Flavonoid (flavonol) | 91.8 ± 2.3 | 3.1 | 2.1–4.5 |
1 Tested in C. violaceum ATCC 31532.