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. 2018 Apr 29;19(5):1326. doi: 10.3390/ijms19051326

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© 2018 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Panel (A) shows single channel recordings from HEK 293 cells transfected with either wild type AChR subunits or wild type AChR subunits plus εL221F-EGFP mutant AChR subunit. Prolonged bursts of openings are evident (downward deflections) stimulated by low concentration of ACh (100 nM). Panel (B) shows mEPC recordings from diaphragm muscle of mutant mice expressing εL221F-EGFP containing AChR (red trace). Endplate currents are prolonged in these mice as a result of the increased duration of AChR burst kinetics.