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. 2018 May 5;19(5):1375. doi: 10.3390/ijms19051375

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Gli inhibition decrease Bcl2 expression and increase Bim expression. The gene expression of human breast cancer cell line (MDA-MB-231) and primary human breast carcinoma T2 cell were assessed by qPCR after 48 h of treatment with DMSO (Control), 40 μM GANT-58 (GANT) or 40 μM HPI-1 (HPI). The mean gene expression of (a) Gli (b) Bcl2 (c) Bim (d) MMP-2 was represented as the mean ± SD of three independent experiments. (* p < 0.05; ** p < 0.01, compared with the cultured treated with DMSO, control).