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Intracellular signals for CRC manifestation via EGFR. CRC, colorectal cancer; EGFR, epidermal growth factor receptor; BRAF, B-rapidly accelerated fibrosarcoma (proto-oncogene); MAPK, mitogen-activated protein kinase; PI3K, phosphoinositide 3-kinase; S6K1, ribosomal protein S6 kinase β-1; PKB, protein kinase B; mTOR, mechanistic target of rapamycin.
