Table II.

Univariate and multivariate analyses of factors associated with survival.

	Univariate analysis			Multivariate analysis
Variables		HR	95% CI	P-value	HR	95% CI	P-value
Age (years)	<55 vs. ≥55	1.409	0.658–3.017	0.378	NA
Sex	Male vs. female	0.575	0.274–1.206	0.143	NA
Lymph nodes metastasis	No vs. yes	0.296	0.129–0.680	0.004a	0.253	0.088–0.728	0.011a
Distant metastasis	No vs. yes	2.707	1.296–5.657	0.008a	2.616	1.034–6.619	0.04 a
Breslow's depth (mm)	≤5 vs. >5	2.105	0.979–4.529	0.057	NA
Clinical stage	I–II vs. III–IV	0.234	0.099–0.551	0.001a	1.239	0.365–4.200	0.731
UHRF1	Low vs. high	3.889	1.718–8.801	0.001a	3.520	1.312–9.442	0.012a
Ki-67	Low vs. high	3.023	1.378–6.631	0.006a	1.239	0.754–4.157	0.189

Univatiate and multivariate analysis, Cox proportional hazard regression model. OS, overall survival time; HR, hazard ratio; CI, confidence interval; NA, not applicable.

^aStatistically significant.