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. 2018 Apr 2;39(6):2604–2612. doi: 10.3892/or.2018.6350

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Copyright: © Shen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Tamoxifen (TAM) resistance of MDA-MB-231 cells is connected with the downregulation of PRMT2 and the upregulation of ER-α36. (A) MCF-7 and MDA-MB-231 cells were incubated with the indicated concentrations of TAM (0, 2, 5 and 7.5 µM) for 36 h or with 7.5 µM TAM for the indicated times (0, 12, 24 and 36 h), and the levels of the indicated proteins were analyzed by immunoblotting. (B) Lysates of MCF-7-shNC and MCF-7-shPRMT2 cells, MDA-MB-231-NC and MDA-MB-231-PRMT2 cells were analyzed by western blotting with the specific antibodies against the proteins as indicated. PRMT2, protein arginine N-methyltransferase 2.