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Crocin inhibited PDGF-BB-induced JAK/STAT3 signaling activation. (A) Representative images showing the protein expression of phosphorylated and total JAK1, JAK2 and STAT3. Bar graph showing the relative protein levels of phosphorylated (B) JAK1, (C) JAK2 and (D) STAT3. *P<0.05 vs. control; #P<0.05 vs. PDGF-BB. PDGF-BB, platelet-derived growth factor-BB; STAT3, signal transducers and activators of transcription; JAK, Janus kinase; p-, phosphorylated.
