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. 2018 Mar 28;17(6):7497–7504. doi: 10.3892/mmr.2018.8811

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Copyright: © Qi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — PL-PTX is associated with ovarian cancer metastasis, mediated by tumor necrosis factor (TNF)-induced inhibition of the ERK/AKT signaling pathway. AntiTNF partially reduced PTX- and PL-PTX-inhibited (A) growth, (B) migration and (C) invasion of CAOV-3 cells compared with control group. (D) PL-PTX and PTX decreased ERK and AKT expression and phosphorylation levels within CAOV-3 cells compared with control group. (E) AntiTNF eliminated decreased ERK and AKT expression and phosphorylation levels induced by PTX and PL-PTX within CAOV-3 cells compared with control group. (F) Inhibition of ERK/AKT signal pathway reduced PTX- and PL-PTX-induced CAOV-3 cell apoptosis compared with control group. Magnification, ×40. *P<0.05. AntiTNF, Anti-TNF neutralizing antibody. AKT, protein kinase B; ERK, extracellular signal-regulated kinase; PL-PTX, pegylated liposomal-paclitaxel; TNF, tumor necrosis factor.

Figure 3. — PL-PTX is associated with ovarian cancer metastasis, mediated by tumor necrosis factor (TNF)-induced inhibition of the ERK/AKT signaling pathway. AntiTNF partially reduced PTX- and PL-PTX-inhibited (A) growth, (B) migration and (C) invasion of CAOV-3 cells compared with control group. (D) PL-PTX and PTX decreased ERK and AKT expression and phosphorylation levels within CAOV-3 cells compared with control group. (E) AntiTNF eliminated decreased ERK and AKT expression and phosphorylation levels induced by PTX and PL-PTX within CAOV-3 cells compared with control group. (F) Inhibition of ERK/AKT signal pathway reduced PTX- and PL-PTX-induced CAOV-3 cell apoptosis compared with control group. Magnification, ×40. *P<0.05. AntiTNF, Anti-TNF neutralizing antibody. AKT, protein kinase B; ERK, extracellular signal-regulated kinase; PL-PTX, pegylated liposomal-paclitaxel; TNF, tumor necrosis factor.