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. 2018 Mar 28;17(6):7497–7504. doi: 10.3892/mmr.2018.8811

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Copyright: © Qi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — ERK/AKT signaling pathway is involved in the activation of the TNF/caspase-3 cascade within ovarian cancer cells. (A) Inhibition of ERKIR decreased caspase-3 expression levels within CAOV-3 cells compared with in the control group. (B) Inhibition of ERKIR inhibited TNF-induced CAOV-3 cell apoptosis compared with in the control group. (C) PL-PTX-induced CAOV-3 cell apoptosis was inhibited via an ERK inhibitor compared with in the control group. **P<0.01. AKT, protein kinase B; ERK, extracellular signal-regulated kinase; ERKIR, ERK/AKT activity; PL-PTX, pegylated liposomal-paclitaxel; TNF, tumor necrosis factor.