Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 5;17(6):7683–7691. doi: 10.3892/mmr.2018.8853

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Tian et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 2. — Effects of Calotropin (0.50 mg/ml) on NSCLC cell apoptosis in vitro. (A) Calotropin promoted the apoptosis of H358 cells, as detected by Annexin V-fluorescein isothiocyanate and propidium iodide staining, and flow cytometry analysis. (B) Calotropin promoted the protein expression levels of caspase-3, caspase-8 and Apaf-1 in H358 cells. (C) Calotropin treatment inhibited the protein expression levels of P53, Bcl-2 and Bcl-w in H358 cells. (D) Calotropin promoted the protein expression levels of Cyto c and JNK. Data are presented as the mean ± standard error mean. **P<0.01, as indicated. NSCLC, non-small-cell lung cancer; Cap, caspase; Apaf-1, apoptotic protease activating factor 1; Bcl-2, B-cell lymphoma 2; Bcl-w, Bcl-2-like protein 2; Cyto c, cytochrome c; JNK, c-Jun N-terminal kinase.