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. 2018 Apr 24;17(6):8039–8046. doi: 10.3892/mmr.2018.8925

Figure 4.

Figure 4.

Pretreatment with DZX attenuates cerebral I/R injury in rats in vivo. (A) Effects of DZX pretreatment on cerebral infarct volumes in rats subjected to I/R. (B) Representative photomicrographs of rat hippocampal sections following histological evaluation demonstrate that pretreatment with DZX attenuated I/R-induced histopathological alterations. Rats were treated with DZX with or without 5-HD and subjected to cerebral ischemia for 2 h followed by 12 h of reperfusion. Sham rats were not subjected to cerebral ischemia. DZX, diazoxide; I/R, ischemia/reperfusion; 5-HD, 5-hydroxydecanoate.