Table IV.
Functional enrichment analysis of the target genes of the 13 lncRNAs with more than 10 target genes.
| A, Upregulated | ||||
|---|---|---|---|---|
| Ontology | ID | Function | Count | FDR |
| BP | GO:0043588 | Skin development | 5 | 0.011708982 |
| BP | GO:0030199 | Collagen fibril organization | 3 | 0.011708982 |
| BP | GO:0071230 | Cellular response to amino acid stimulus | 3 | 0.012776741 |
| BP | GO:0043589 | Skin morphogenesis | 2 | 0.012776741 |
| BP | GO:0070208 | Protein heterotrimerization | 2 | 0.016397947 |
| CC | GO:0005583 | Fibrillar collagen trimer | 3 | 0.000116529 |
| CC | GO:0098643 | Banded collagen fibril | 3 | 0.000116529 |
| CC | GO:0098644 | Complex of collagen trimers | 3 | 0.000426968 |
| CC | GO:0005581 | Collagen trimer | 3 | 0.016659231 |
| CC | GO:0044420 | Extracellular matrix component | 3 | 0.037435206 |
| MF | GO:0048407 | Platelet-derived growth factor binding | 3 | 0.000119244 |
| MF | GO:0005201 | Extracellular matrix structural constituent | 3 | 0.016290955 |
| F | GO:0005198 | Structural molecule activity | 6 | 0.036696011 |
| MF | GO:0019838 | Growth factor binding | 3 | 0.040871579 |
| KEGG | hsa04974 | Protein digestion and absorption | 3 | 0.002473586 |
| KEGG | hsa05146 | Amoebiasis | 3 | 0.002473586 |
| KEGG | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 3 | 0.002473586 |
| KEGG | hsa04611 | Platelet activation | 3 | 0.003235067 |
| KEGG | hsa04512 | ECM-receptor interaction | 2 | 0.026270733 |
| B, Downregulated | ||||
| Ontology | ID | Function | Count | FDR |
| BP | GO:0055078 | Sodium ion homeostasis | 2 | 0.164234693 |
| BP | GO:0042391 | Regulation of membrane potential | 3 | 0.164234693 |
| BP | GO:0034220 | Ion transmembrane transport | 4 | 0.164234693 |
| BP | GO:0007416 | Synapse assembly | 2 | 0.164234693 |
| BP | GO:0035725 | Sodium ion transmembrane transport | 2 | 0.164234693 |
| CC | GO:1902495 | Transmembrane transporter complex | 3 | 0.02856848 |
| CC | GO:1990351 | Transporter complex | 3 | 0.02856848 |
| CC | GO:0098794 | postsynapse | 3 | 0.02856848 |
| CC | GO:0030424 | Axon | 3 | 0.02856848 |
| CC | GO:0030426 | Growth cone | 2 | 0.041273443 |
| MF | GO:0015075 | Ion transmembrane transporter activity | 4 | 0.011272955 |
| MF | GO:0022891 | Substrate-specific transmembrane transporter activity | 4 | 0.011272955 |
| MF | GO:0022857 | Transmembrane transporter activity | 4 | 0.011272955 |
| MF | GO:0005216 | Ion channel activity | 3 | 0.011272955 |
| MF | GO:0046873 | Metal ion transmembrane transporter activity | 3 | 0.011272955 |
FDR, false discovery rate; Count, number of enriched genes; GO, gene ontology; BP, biological process; MF, molecular function; CC, cellular component; KEGG, Kyoto Encyclopedia of Genes and Genomes.