Table 1.
Micro-computed tomography evaluation of cortical bone morphology in the femur following repeated TCDD dosing
| Sex | TCDD (µg/kg) |
Inner Perimeter (mm) |
Outer Perimeter (mm) |
Marrow Area (mm2) |
Cortical Area (mm2) |
Mineral Density (mg/cm3) |
Mineral Content (µg) |
|
|---|---|---|---|---|---|---|---|---|
| Sex Comparison | Female | 0 | 3.54 ± 0.05 | 4.84 ± 0.04 | 0.89 ± 0.02 | 0.81 ± 0.02 | 667 ± 14 | 10.7 ± 0.5 |
| 30 | 3.47 ± 0.06 | 4.81 ± 0.03 | 0.87 ± 0.03 | 0.80 ± 0.02 | 669 ± 11 | 10.4 ± 0.3 | ||
| Male | 0 | 3.68 ± 0.06 | 5.02 ± 0.06 | 0.95 ± 0.02 | 0.84 ± 0.06 | 662 ± 16 | 10.6 ± 0.8 | |
| 30 | 3.66 ± 0.02 | 4.90 ± 0.01 | 0.95 ± 0.01 | 0.76 ± 0.01 | 635 ± 7 | 8.9 ± 0.3 | ||
| Dose Response | Male | 0 | 3.85 ± 0.06 | 4.95 ± 0.06 | 1.05 ± 0.04 | 0.69 ± 0.02 | 766 ± 16 | 9.6 ± 0.6 |
| 0.01 | 3.66 ± 0.05 | 4.84 ± 0.06 | 0.95 ± 0.02 | 0.72 ± 0.03 | 769 ± 22 | 10.4 ± 0.7 | ||
| 0.03 | 3.63 ± 0.09 | 4.90 ± 0.04 | 0.94 ± 0.04 | 0.74 ± 0.04 | 744 ± 12 | 10.4 ± 0.9 | ||
| 0.1 | 3.62 ± 0.06 | 4.93 ± 0.05 | 0.94 ± 0.03 | 0.78 ± 0.03 | 801 ± 22 | 12.2 ± 0.7 | ||
| 0.3 | 3.75 ± 0.04 | 4.97 ± 0.02 | 1.01 ± 0.02 | 0.76 ± 0.02 | 725 ± 27 | 10.4 ± 0.5 | ||
| 1 | 3.66 ± 0.08 | 4.88 ± 0.05 | 0.94 ± 0.03 | 0.73 ± 0.05 | 735 ± 13 | 10.1 ± 1.0 | ||
| 3 | 3.65 ± 0.05 | 4.86 ± 0.06 | 0.94 ± 0.02 | 0.73 ± 0.01 | 702 ± 10 | 9.7 ± 0.3 | ||
| 10 | 3.64 ± 0.07 | 4.86 ± 0.03 | 0.94 ± 0.03 | 0.75 ± 0.04 | 702 ± 19 | 9.9 ± 0.8 | ||
| 30 | 3.67 ± 0.08 | 4.75 ± 0.07* | 0.93 ± 0.03* | 0.63 ± 0.03 | 652 ± 14* | 7.2 ± 0.6 |
*
Statistical significance (* p ≤ 0.05) was determined using either a Student’s t-test (sex comparison study) or a one-way ANOVA analysis followed by Dunnet’s post hoc test (dose-response study).