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. Author manuscript; available in PMC: 2018 Jul 3.
Published in final edited form as: Nature. 2018 Jan 3;553(7688):291–294. doi: 10.1038/nature25178

Figure 2. treA is responsible for trehalose metabolism.

Figure 2

a, Trehalose metabolism operon found in all C. difficile strains; consisting of a phosphotrehalase (treA) and its transcriptional regulator (treR). b, RT027 strains strongly induce treA at 50 μM trehalose and at a significantly higher level than non-RT027 strains (n=4 biologically independent samples per trehalose concentration/strain). Bars are average fold increase, error bars are s.d.; p values derived from t-test (2-tailed) and Holm corrected for multiple comparisons. c, Structure of TreR monomer highlighting proximity of L172I mutation to trehalose-6-P binding pocket.