Table 1. Twenty genes enriched in gWAT of WRG mice compared to WG.

Gene symbol	Gene name	Log2 FC WC vs Weight gain	Function	Module
Irgm2	Immunity-related GTPase family M protein 2	2.22	Autophage	8 pink
Nkg7	Natural killer cell group 7 sequence	2.14	Unknown function	8 pink
Slamf6	SLAM family member 6	2.09	NK cell receptor	3 turquoise
Ikzf3	Zinc finger protein Aiolos	2.05	B-cell differentiation	8 pink
Cd3g	T-cell surface glycoprotein CD3 gamma	2.02	T-cell receptor	8 pink
Cd22	B-cell receptor CD22	1.92	B-cell receptor	3 turquoise
Ccl5	C-C motif chemokine 5	1.89	Chemokine	8 pink
Aif1	Allograft inflammatory factor 1	1.79	Phagocytosis	8 pink
Gbp2	Interferon-induced guanylate-binding protein 2	1.62	Antiviral activity	8 pink
Cd83	CD83 antigen	1.51	Costimulator	3 turquoise
Rasgrp1	RAS guanyl-releasing protein 1	1.26	T/B-cell development,	8 pink
Ly86	Lymphocyte antigen 86	1.21	Innate immune response	3 turquoise
C1qc	Complement C1q subcomponent subunit C	1.19	Innate immune response	3 turquoise
C1qb	Complement C1q subcomponent subunit B	1.17	Innate immune response	3 turquoise
H2-DMb1	Class II histocompatibility antigen, M beta 1 chain	0.88	MHC class II	5 yellow
Ptpn18	Tyrosine-protein phosphatase non-receotir type 18	0.79	Protein phosphatase	4 magenta
H2-Aa	H-2 class II histocompatibility antigen, A-K alpha chain	0.71	MHC class II	8 pink
Cd74	H-2 class II histocompatibility antigen, gamma chain	0.65	Costimulator	8 pink
Ccdc57	Coled-coil domain -containing protein 57	−0.17	Unknown function	2 red
Agt	Angiotensinogen	−2.31	Angiotensin maturation	3 turquoise

Abbreviations: gWAT, gonadal white adipose tissue; WRG, weight regain.

Candidates that were enriched to adipose tissue (tissue expression information was derived from ‘GeneAnalytics’ in GeneCards) were collected from module pink associated subnetworks. Bold: FDR<0.05.