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. 2017 Jul 20;23(5):1278–1286. doi: 10.1038/mp.2017.138

Figure 4.

Figure 4

Disruption of the FBXW7/DISC1 complex using cell-permeable peptide analogs of the DISC1 PD upregulate DISC1 protein levels in HEK293 cells. (a) HEK293 cells were treated with the indicated peptides (sequences delineated below Figure 4a) for 3 h (100 μM) before cellular lysates were prepared and blotted for DISC1. ‘Str’ represents stearoylated peptides and ‘Us’ represents unstearoylated peptides. (b) HEK293 cells were treated with the indicated concentrations of peptides I11 and I14 for 3 h before cellular lysates were prepared and blotted for DISC1.