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. 2017 May 23;23(5):1127–1133. doi: 10.1038/mp.2017.104

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Vortioxetine reduced blood-oxygen-level-dependent (BOLD) signal within (a) the right dorsolateral prefrontal cortex (dlPFC) and (b) left hippocampus across all participants. Red voxels show significant difference (cluster corrected P<0.05) between treatment groups in the change of N-back–0-back contrast across treatment within the prespecified anatomical masks across all subjects. Bar charts illustrate the mean (±s.e.m.) of the extracted signal change separated by treatment and subject group.