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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Semin Cancer Biol. 2017 Dec 2;54:121–130. doi: 10.1016/j.semcancer.2017.11.021

Figure 1. RAS protein maturation processes and inhibitors.

Figure 1

Posttranslational modifications of RAS polypeptides mediate RAS trafficking through the endoplasmic reticulum and Golgi, and subsequent trafficking to the plasma membrane as described in the text. In the specific case of KRAS4B, chaperone protein PDE6δ (PDE) is critical for cytosolic trafficking; NRAS appears to be chaperoned by VPS35 binding to its farnesyl group. Small molecule inhibitors discussed in the text are shown for each step in RAS membrane targeting.