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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Curr Opin Neurobiol. 2017 Dec 1;50:33–41. doi: 10.1016/j.conb.2017.11.007

Figure 3.

Figure 3

Electrical I/O connection and long-term stable recording at the single-neuron level using mesh electronics. (a) Quantitative and scalable high throughput I/O connection by a plug-and-play interface: structural design of the plug-and-play mesh electronics (I), insertion of I/O pads of plug-and-play mesh electronics into a ZIF connector (II), and compact headstage comprising mesh electronics inserted into the ZIF connector (red arrows) on a PCB that provides an interface to a standard Omnetics connector (yellow arrows) for recording (III) [45]. (b) 16-channel multiplexed recording of LFP (background heat map) and single-unit firing (foreground black traces) from the same mouse brain at 2 and 4 months post injection. The relative positions of all 16 recording electrodes are marked by red dots in the schematic (leftmost panel), and span the somatosensory cortex to hippocampus. (c) Chronic tracking of same individual neurons by time-dependent PCA (I) and firing rate analysis (II) that allows for study of brain aging on the single-neuron level by tracking firing rate evolution of the same three individual neurons from 35 to 57 weeks of age (III) [40].