Table 2.

Cluster analysis of the proteins up-regulated by IL-3 versus vehicle (resting)

DAVID 6.8 Functional Annotation Clustering

Cluster	Functional annotation	# of detected proteins*	# of upregulated proteins**	P value (Benjamini) (DAVID)***	% upregulated versus detected
Translation and protein processing	Translation	153	96	2.8 ×10−31	62.7
	Protein biosynthesis	128	80	2.1 ×10−46	62.5
	Protein transport	355	123	2.8 ×10−16	34.6
	Golgi apparatus	348	72	4.9 ×10−8	20.6
Cytoskeleton	Cytoskeleton	150	89	3.4 ×10−13	59.3
	Actin cytoskeleton organization	71	38	9.7 ×10−5	53.5
	Cytoskeleton organization	112	55	1.4 ×10−3	49.1
Nucleotide binding/RNA	Nucleotide binding	707	229	1.2 ×10−9	32.4
	RNA binding	395	122	3.3 ×10−19	30.8
Vesicle/transport	Vesicle-mediated transport	306	96	3.9 ×10−13	31.4
	Vesicle	280	86	3.2 ×10−7	30.7
Intracellular signaling	ATP binding	608	140	9.4 ×10−4	23.0
	Kinase	263	60	1.2 ×10−2	22.8
	GTPase activity	97	34	3.0 ×10−4	35.0
Cell death	Regulation of cell death	330	92	2.4 ×10−4	27.9
	Positive regulation of cell death	182	50	1.6 ×10−2	27.4
Leukocyte function	Leukocyte migration	45	12	4.7 ×10−2	26.6
	Leukocyte adhesion	11	8	6.5 ×10−2	72.7

^*: number of detected proteins among the 5385 detected proteins that are part of the indicated functional annotation as determined by DAVID analysis

^**: number of proteins up-regulated by IL-3 (q<0.05) and part of the indicated functional annotation as determined by DAVIS analysis

^***: adjusted enrichment p value (Benjamini correction). The smaller, the more enrichment of the IL-3-upregulated proteins in the indicated functional annotation

%: percentage of proteins IL-3-up-regulated among the total proteins detected and present in the indicated functional annotation

Underlined are clusters for which a list of proteins is shown in Supplemental Tables 2 and 3