Table 4.

Cluster analysis of the proteins hyper-phosphorylated by IL-3 (q<0.01 and log 2 fold change > 0.25)

DAVID 6.8 Functional Annotating Clustering

Cluster	Functional annotation
Signaling	Kinases (72; p=1.6 ×10−15)
	Serine/threonine-protein kinase (46, p=1.2 ×10−11)
	Regulation of Ras protein signal transduction (25, p=3.9 ×10−4)
	MAPKKK cascade (21, p=3.4 ×10−3)
	Transmembrane receptor protein tyrosine kinase signaling pathway (21, p=2.2 ×10−2)
Cytoskeleton	Cytoskeleton (96; p=1.3×10−9)
	Actin cytoskeleton (29; p=8.9×10−6)
RNA/translation	RNA-binding (41, p=5.1×10−5)
	mRNA transport (13, p=9.6×10−5)
	Ubiquitin-associated/translation elongation factor EF1B (11, p=1.3×10−4)
	Posttranscriptional regulation of gene expression (21, p=1.2×10−2)
	Translation regulation (9, p=1.5×10−2)
	mTOR signaling pathway (9, p=3.4×10−2)
	Golgi apparatus (47, p=2.7×10−2)
Intracellular movement	Vesicle-mediated transport (50, p=3.4×10−5)
	Nucleocytoplasmic transport (19, p=3.6×10−3)
	Membrane-bounded vesicle (36, p=8.0×10−3)
Other cell responses	Focal adhesion (16, p=6.0×10−5)
	Positive regulation of apoptosis (33, p=1.5×10−2)

In parentheses: number of proteins hyper-phosphorylated by IL-3 (q<0.01 and log 2 fold change > 0.25) for each functional annotation; p values (Benjamini correction)

Underlined are clusters for which a list of proteins is shown in Supplemental Tables 5, 6, 7 and 8