Table 2.

Survival and final mean body weight for male and female rats and mice.

Dose (mg/kg)	0	3	15	50
Male rats
Survivala	36	35	38	27*
Mean body wt. (g)b % control	673 ± 14 –	669 ± 12 99%	695 ± 14 103%	678 ± 18 101%
Female rats
Survival	38	40	34	38
Mean body wt. (g) % control	390 ± 9 –	374 ± 11 96%	358 ± 10 92%	314 ± 12† 81%

Dose (mg/kg)	0	3	30	100
Male mice
Survival	30	33	31	18 month termination
Mean body wt. (g) % control	45.7 ± 1.5 –	46.4 ± 1.1 102%	38.2 ± 1.1† 84%
Female mice
Survival	33	35	38	18 month termination
Mean body wt. (g) % control	51.7 ± 1.4 –	53.4 ± 1.4 103%	48.5 ± 1.2 94%

^*Survival is significantly reduced compared to the control group, by Cox’s life table pairwise comparison, p < 0.05.

^†Body weight is significantly reduced compared to the control group, by Dunnett’s test, p < 0.05.

^aNumber of animals surviving to end of the study of 50 per group starting the study.

^bMean ± standard error of the mean.