PET/CT-based response analysis. (A) The relative change in mean uptake (day2/baseline) for all NS, saline and sham treated animals in the 18F-FDG (left panel), 18F-FLT (middle panel) and 18F-FET (right panel) studies. (B) The correlation between the relative change in uptake and survival. (C) Tumor volumes derived from CT scans at baseline and day 7. Data shown is mean ± S.E.M and *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. 18F-FDG: n = 7 (NS group), n = 6 (saline group), and n = 7 (sham group). 18F-FLT: n = 8 (NS group), n = 7 (saline group), and n = 6 (sham group). 18F-FET: n = 7 (NS group), n = 7 (saline group), and n = 7 (sham group).