Fig. 5.

(GGGGCC)₆₆ repeat expansion overexpression does not alter Tmem106b protein levels in mouse brain. (a) Western blot of brain tissue obtained from 2R- or 66R-injected wild-type mice using antibodies against various lysosomal proteins. Gapdh was used as a loading control. (b) Quantification of Tmem106b protein levels by Western blot as depicted in panel a. The graph represents the mean ± S.E.M. by Student’s t-test (n = 8 for 2R; n = 12 for 66R ); NS, not significant