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. 2018 May 31;37:111. doi: 10.1186/s13046-018-0778-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Desmosomal gene silencing diminished the effect of SOX30 overexpression on proliferation, migration and invasion of A549 and LTEP-a-2 cells. a SOX30, DSP, JUP and DSC3 expression were confirmed by WB in A549 and LTEP-a-2 cells. b MTS assays were performed to analyze cell proliferation of A549 and LTEP-a-2 cells cotransfected with desmosomal gene miRNA and SOX30 expression vector. *P < 0.05; **P < 0.01. c The effect of increasing SOX30 expression with decreasing desmosomal gene expression on cell growth was further confirmed by colony formation assay in A549 and LTEP-a-2 cells. d Assessment of the effects of the expression of SOX30 and desmosomal gene, respectively, on cell migration and invasion in A549 and LTEP-a-2 cells