Table 5.
Maternal characteristics and clinical risk factors associated with early- and late-onset preeclampsia
| Early onset preeclampsia | Late onset preeclampsia | Ratio of Relative risk (95%CI) | P Value | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Crude Relative risk (95%CI) |
P Value | Adjusted Relative risk (95%CI)a |
P Value | Crude Relative risk (95%CI) |
P Value | Adjusted Relative risk (95%CI)a |
P Value | ||||||||
| Age at delivery | |||||||||||||||
| 15–24 | Reference | Reference | Reference | Reference | Reference | ||||||||||
| 25–34 | 1.79 | (1.69–1.90) | < 0.01* | 1.73 | (1.63-1.84) | < 0.01* | 1.33 | (1.27-1.39) | < 0.01* | 1.36 | (1.30-1.43) | < 0.01* | 1.27 | (1.78-1.37) | < 0.01* |
| 35–55 | 3.84 | (3.60–4.10) | < 0.01* | 3.21 | (2.99-3.44) | < 0.01* | 2.31 | (2.19-2.42) | < 0.01* | 2.28 | (2.16-2.40) | < 0.01* | 1.41 | (1.29-1.54) | < 0.01* |
| Number of prior ≧20 weeks births (parity) | |||||||||||||||
| 0 | 1.06 | (1.02–1.09) | < 0.01* | 1.39 | (1.34-1.44) | < 0.01* | 1.65 | (1.59-1.70) | < 0.01* | 1.95 | (1.89-2.02) | < 0.01* | 0.71 | (0.68-0.75) | < 0.01* |
| ≥ 1 | Reference | Reference | Reference | Reference | Reference | ||||||||||
| Acute Coronary syndromeb | |||||||||||||||
| No | Reference | Reference | Reference | Reference | Reference | ||||||||||
| Yes | 2.59 | (2.04–3.28) | < 0.01* | 1 | (0.78-1.30) | 0.98 | 1.45 | (1.11–1.90) | < 0.01* | 0.77 | (0.58-1.02) | 0.07 | 1.3 | (0.89–1.90) | 0.09 |
| Chronic ischemic heart disease | |||||||||||||||
| No | Reference | Reference | Reference | Reference | Reference | ||||||||||
| Yes | 3.44 | (2.83–4.17) | < 0.01* | 0.84 | (0.68-1.04) | 0.11 | 2.45 | (2.02–2.98) | < 0.01* | 0.92 | (0.74-1.14) | 0.45 | 0.91 | (0.67–1.24) | 0.28 |
| Stroke | |||||||||||||||
| No | Reference | Reference | Reference | Reference | Reference | ||||||||||
| Yes | 2.96 | (2.37–3.68) | < 0.01* | 1.33 | (1.05-1.68) | 0.02* | 2.07 | (1.67-2.58) | < 0.01* | 1.28 | (1.02-1.61) | 0.03* | 1.04 | (0.75-1.44) | 0.4 |
| Diabetes mellitus | |||||||||||||||
| No | Reference | Reference | Reference | Reference | Reference | ||||||||||
| Yes | 5.34 | (4.91–5.81) | < 0.01* | 1.9 | (1.71-2.10) | < 0.01* | 3.76 | (3.46-4.08) | < 0.01* | 2.03 | (1.85-2.23) | < 0.01* | 0.94 | (0.82-1.08) | 0.19 |
| Chronic hypertension | |||||||||||||||
| No | Reference | Reference | Reference | Reference | Reference | ||||||||||
| Yes | 22.73 | (21.5–24.0) | < 0.01* | 16.8 | (15.7-18.0) | < 0.01* | 12.21 | (11.5-13.0) | < 0.01* | 9.85 | (9.19-10.6) | < 0.01* | 1.71 | (1.55-1.88) | < 0.01* |
| Hyperthyroidism | |||||||||||||||
| No | Reference | Reference | Reference | Reference | Reference | ||||||||||
| Yes | 1.68 | (1.53–1.83) | < 0.01* | 1.18 | (1.07-1.29) | < 0.01* | 1.48 | (1.36-1.60) | < 0.01* | 1.21 | (1.12-1.32) | < 0.01* | 0.98 | (0.86-1.10) | 0.34 |
aAdjusted Relative risk: adjusted for with age at delivery, income, urbanization, parity, acute coronary syndrome, chronic ischemic heart disease, stroke, diabetes mellitus, chronic hypertension and hyperthyroidism
bAcute Coronary syndrome included myocardial infarction and unstable angina
*P < 0.05