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. 2018 May 31;18:46. doi: 10.1186/s12866-018-1189-5

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — a Functional Distribution of Essential Genes. The essential genes of Y. pseudotuberculosis were qualitatively assessed and grouped for their predicted function, excluding phage-related genes. b Venn Diagram depicting relationship between genes that were essential for in vitro growth in both Y. pseudotuberculosis and Y. pestis, and those that were found to be uniquely essential to either species. Examples of genes are provided in each condition. c Essential Genes Can Be Used to Predict Antibiotic Sensitivity. Y. pseudotuberculosis IP32953 in BAB growth media was incubated at 28 °C with a titrated dose of actinonin, prior to enumeration of colony forming units. Student’s T-test conducted versus the untreated condition (* = p < 0.01)