Table 7.

FACT-An: Important Change Score Estimates Using Distribution-based, anchor-based, and Linking Methods

FACT-An total/ subscale	1 SEM	0.5 SD	Vitality 3–4, Week 9	Vitality 3–4, Week 13/17	Physical functioning 2.8–4.2, Week 9	Physical functioning 2.8–4.2, Week 13/17	PCS 2–4, Week 9	PCS 2–4, Week 13/17	Linking vitality	Linking physical functioning	Linking PCS
Total	10.4	15.0	8.7	7.8	4.8	9.1	4.4	7.1	7.50	8.11	6.38
Anemia subscale	6.2	7.5	5.2	4.2	1.3	5.5	2.5	4.7	3.75	4.05	3.19
Fatigue subscale	5.2	5.7	4.0	3.2	2.1	3.9	2.1	3.6	2.88	3.11	2.45
General	6.4	8.5	3.6	3.6	3.5	3.6	1.9	2.4
Physical Well-Being	2.3	2.7	0.7	1.5	−0.4	1.3	0.3	1.3
Functional Well-Being	2.7	3.3	0.6	0.4	1.7	2.4	0.0	−0.4
Social Well-Being	2.8	2.9	0.9	0.7	0.5	−0.5	0.9	1.7
Emotional Well-Being	2.5	2.4	1.2	1.0	1.7	0.3	0.7	−0.2

Abbreviations: FACT-An Functional Assessment of Cancer Therapy-Anemia, PCS Physical Component Summary, SD standard deviation, SEM standard error of measurement