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. 2018 May 31;11:8. doi: 10.1186/s13040-018-0166-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Power for SAFE alternative settings. Statistical power for results with alternative settings alongside default settings for SAFE. The alternative settings tested include 10,000 permutations (‘-10 k’ labels) and bootstrap sampling (‘-boot’ labels). The default setting is with 1000 permutations (‘-1 k’ labels). All power values are shown as a significance value of 0.05. a The KRAS.PROSTATE_UP.V1_DN pathway has been differentially expressed. b The TGF-β SIGNALING pathway has been differentially expressed