Table 2.
Regional brain volume change and correlation with change in cognitive scores.
| Number of voxels (ml) | x y z | t |
ta Adj. sex |
|
|---|---|---|---|---|
| Volume reduction Whole sample | ||||
| Substantia Innominata Region (gray matter) | 2358 (8.0) | 1.5 0–10.5 | 5.9 | 5.9 |
| R Lateral Temporal Cortex (gray matter) | 573 (1.9) | 49.5–18 −10.5 | 4.3 | 4.2 |
| L Lateral Temporal Cortex (gray matter) | 316 (1.1)b | −63 −18 −6 | 4.0 | 3.9 |
| R Orbitofrontal Cortex (gray matter) | 550 (1.9) | 19.5 37.5–21 | 5.4 | 5.3 |
| R Hippocampus Region (white matter) | 1375 (4.6) | 27–33 −6 | 5.0 | 4.9 |
| L Arcuate Fasciculus (white matter) | 1314 (4.4) | −43.5 30–7.5 | 5.8 | 5.8 |
| Volume reduction Cognitive impairment progression group > remaining sample | ||||
| Substantia Innominata Region (gray matter) | 907 (3.1) | 0 1.5–10.5 | 4.8 | 5.1 |
| L Hippocampus (gray matter) | 365 (1.2) | −30 − 25.5 −13.5 | 4.1 | 4.1 |
| Correlation between change in volume and change in cognitive score | ||||
| Memory-Word List Learning | ||||
| L Hippocampus-Amygdala (gray matter) | 444 (1.5) | −25.5 −25.5 −10.5 | 3.9 | 3.5 |
| R Thalamus (gray matter) | 665 (2.4) | 10.5–16.5 1.5 | −4.2 | −3.9 |
| Verbal Comprehension | ||||
| L Wernicke Area (gray matter) | 759 (2.6) | −49.5 −15 −10.5 | 4.0 | 4.0 |
| L Arcuate Fasciculus (white matter) | 1402 (4.7) | −36 0 30 | 4.0 | 3.5 |
| Object Recognition | ||||
| L Caudate Nucleus (adjacent white matter) | 1591 (5.4) | −12 18 1.5 | −4.7 | −4.4 |
| Executive Function-Prospective Memory | ||||
| L Prefrontal (gray matter) | 6578 (22.2) | −25.5 6 37.5 | 5.3 | 5.2 |
| R Prefrontal (gray matter) | 2773 (9.4) | 39 49.5 22.5 | 4.3 | 4.2 |
| Paracentral Lobule (gray matter) | 4850 (16.4) | 12–15 70.5 | 4.5 | 4.4 |
| L Prefrontal (white matter) | 5154 (17.4) | −19.5 16.5 24 | 6.5 | 6.3 |
| R Prefrontal (white matter) | 6478 (21.9) | 24 31.5 18 | 6.9 | 7.1 |
| L Inferior Temp/Hippocampus (white matter) | 1019 (3.4) | −28.5 −18 −13.5 | 3.8 | 3.7 |
| R Inferior Temp/Hippocampus (white matter) | 2079 (7.0) | 39–28.5 −21 | 3.9 | 3.9 |
x y z, coordinates (mm) given in Montreal Neurological Institute (MNI) space. Statistics at corrected threshold PFWE < 0.05 estimated using Monte Carlo simulations.
a
Adjusted by sex.
b
Subthreshold.