Fig. 3.

Early changes in axial diffusivity (E1) after injury were extensive, albeit transient. (A) E1 differences between injured and sham rats covered a large number of gray and white matter areas. Gray matter regions with increased E1 included the cingulate (Cg), sensory (S1), motor (M1/M2), and visual (V1/V2) cortices. White matter areas with increased E1 were found in the corpus callosum (cc), cingulum (cg), internal capsule (ic), stria medularis (sm), superior thalamic radiation/medial lemniscus (ml), and fimbria (fi), as well as the medial longitudinal fasciculus (mlf), all cerebellar peduncles (scp, mcp, and icp), and cerebellar white matter (cbw). Voxel-wise data are presented as t maps, cluster-corrected for multiple comparisons, and thresholded at the 0.05 significance level; R = right (ipsilateral hemisphere), L = left (contralateral hemisphere); scalebar = 2 mm. (B) On a regional level, the only significant finding was an increase in E1 (mm²/s × 10⁻⁴) with normal maturation for the optic tract (p = .04). ROI data are presented as box plots where red line = median, box = quartiles, whiskers = range, + = outliers. Key: cp, cerebral peduncle; Hb, habenular nuclei; icp, inferior cerebellar peduncle; mcp, middle cerebellar peduncle; mt, mammillothalamic tract; Pa, paraventricular hypothalamic nucleus; PAG, periaqueductal gray; Pn, pontine nuclei; S1, primary somatosensory cortex; scp, superior cerebellar peduncle; yc, young control; yb, young blast; oc, old control; ob, old blast.