Suppl. Fig. 2.

Fractional anisotropy (FA) following rmbTBI. (A) At 7 days post-injury, FA differences were evident in a number of white and gray matter regions. Among white matter structures, the external capsule, (caudal) corpus callosum (cc), optic tract (opt), and cerebral peduncle (cp) had reduced FA, while the internal capsule (unilateral) and cerebellar white matter (cbw) had increased FA. Among gray matter regions, FA was reduced in the primary and secondary somatosensory cortex (S1/S2) and postsubiculum (Post), and increased in the septum (Spt), striatum (CPu, caudate putamen), motor (M1/M2) and cingulate (A30) cortex. (B) At 90 days post-injury, FA was generally higher in injured rats relative to their age-matched controls. FA increases were mostly evident in gray matter regions, including the striatum, amygdala (Amy), hippocampus (Hc), hypothalamus, centro-medial thalamic nucleus (CM), and the reticular formation (e.g., Gi, gigantocellular reticular nucleus). White matter tracts with higher FA included the cerebral peduncle (cp), inferior cerebellar peduncle (icp), and cerebellar white matter (cbw). (C) White and gray matter areas showing significant injury x age interactions on FA. White matter regions included the lateral olfactory tract (lo), opt, cc, cp, icp, cbw, as well as the spinal trigeminal tract (sp5), medial longitudinal fasciculus (mlf), and cranial nerve 7 (7n). Gray matter regions included the insula (Ins), cingulate cortex (Cg), hypothalamus, S1, Hc, substantia nigra, para- and post-subiculum (Post), and the anterior and posterolateral cortical nuclei of the amygdala (Amy). Voxel-wise data are presented as t maps, uncorrected (p < .05); R = right (ipsilateral hemisphere), L = left (contralateral hemisphere); scalebar = 2 mm.