Table 2.
Summary of bio-sensing applications shown by iron oxide nanoparticles
| Nanoparticle/material | Size (nm) | Applications/results | References |
|---|---|---|---|
| Microgel embedded IONP-GOx-HRP | ~ 200 | Exhibited peroxidase like activity. Colorimetric detection of glucose was carried in a single step at pH 5.5 | Wu et al. (2015a) |
| Prussian blue FeCo NPs | 40–50 | PBNPs catalyzed the oxidation of NADH by H2O2 to form NAD+ (showed dehydrogenase like activity). FeCo NPs catalyzed chemiluminescence generation in presence of H2O2 and luminol (showed Peroxidase like activity). Glucose detection was performed using FeCo NPs | Vazquez-Gonzalez et al. (2017) |
| Cu(HBTC)-1/Fe3O4-AuNPs nanosheets with ssDNA | 5.99 ± 2.58 | Enhanced TMB oxidation was observed in presence of single stranded DNA. 2D bimetallic immobilized MOF nanosheets were applied for detection of H2O2 (2.86–71.43 nM range) and glucose (12.86 to 257.14 µM range) | Tan et al. (2017) |
| Fe3O4@SiO2/MWNT (SiO2 coated Fe3O4 NPs dispersed on Multiwalled-carbon nano tubes) | 5–15 | Biosensor was applied for detection of glucose (3 µM–14 mM range) and cholesterol (10 µM–4 mM range) | Ramaprabhu (2011) |
| FeNPs@Co3O4 (IONPs loaded in Co3O4 hollow nanocages) | 900 | Applied for glucose detection with a linear range of 0.5–30 µM (limit of detection was 0.05 µM) | Zhao (2018) |
| Fe3O4-nanoparticles-modified carbon paste electrodes | – | Creatinine was determined with a detection limit of 2.0 × 10−7 mol L−1 | Kacar et al. (2013) |
| Graphene oxide/Fe3O4 nanocomposite | 50 | Biosensor for determination of glucose, with a range of 0.5–10 mM | Wang (2018) |
| MWCNT doped with Ni, Zn, Fe | 10–50 | Serotonin was determined with a detection limit of 5.98 × 10−3 µM–62.8 µM | Fayemi et al. (2017) |
| Chitosan-IONPs with urease | – | Applicable for the detection of urea | Ali (2013) |
| IONPs | 19.5 | Brucella antibodies detection with a detection limit of 0.05 µg mL−1 | Fornara et al. (2008) |
| Fe3O4 NPs | 13 ± 3.5 | ATP-mediated peroxidase like activity of Fe3O4 NPs was observed at pH 7.4. Glucose detection was carried in a single step at physiological pH with a colorimetric detection limit of 50 µM | Vallabani et al. (2017) |
| Fe3O4 NPs with Fe3+ AMP shell | 10–20 | Glucose detection was demonstrated with a detection limit of 1.4 µM | Liang et al. (2016) |
| Fe3O4 NPs | ~ 13 | Exhibited peroxidase like activity. Can be applicable as a fluorescent turn-off system for urinary protein detection | Yang et al. (2017) |