Table 3.
Summary of iron oxide based nanoparticles for hyperthermia and photo thermal therapy
| Nanoparticle/material | Size (nm) | Applications/results | References |
|---|---|---|---|
| IONPs (nano-cubes) | 20 | The dual mode (hyperthermia and PTT) of treatment amplified the heating effect by two- to fivefold in comparison with magnetic stimulation alone. Results showed that in both in vitro (SKOV3) (ovarian cancer), PC3 (prostate cancer) and A431 (epidermoid cancer) and in vivo (A431 cancerous cells were injected in nude NMRI mice) complete cell death was observed after dual mode exposure | Espinosa et al. (2016) |
| ICG/Fe3O4 loaded PLGA NPs | Fe3O4: 10 Total shell: ~300 |
Used as an efficient treatment by PTT. In vitro treatment of NPs to MCF-7 breast cancer cells confirmed the damage to cells and in vivo studies demonstrated IONPs can be used as an effective agent for tumor ablation | Niu et al. (2017) |
| Carboxyl-amine functionalized SPIONs based ferrofluids | ~ 20 | In vitro hyperthermia studies revealed terephthalic acid (TA) and aminoterephthalic acid (ATA) coated SPIONs induced ~ 90% cell death in breast cancer cells (MCF-7) | Kandasamy (2018a) |
| IONPs with HSA | 10 | Used for thermal therapy. MNPs exhibited a saturation magnetization of 63 emu g−1 at 310 K and produced a localized heat in presence of an alternating magnetic field | Mazario (2017) |
| Clustered magnetic Fe3O4 NPs | Fe3O4: 15 Clustered Fe3O4: 225 |
Used for PTT. The clustered NPs induced high temperature and proved to be more cytotoxic against A549 cells both in vitro and in vivo | Shen et al. (2015) |
| SPIONs | 6–10 | Hyperthermia based thermotherapy for liver cancer treatment | Kandasamy (2018b) |
| Crystallized IONPs (HCIONPs) | 15 | Showed effective PTT against SUM-159 tumor-bearing mice | Hongwei Chen (2014) |
| PEGylated Fe@ Fe3O4 (PEGylated iron/iron oxide core/shell NPs) | 13.4 ± 0.8 | These multifunctional NPs can be applied for targeting, MRI imaging and PTT | Zhou et al. (2014) |
| Fe3O4@CMCT (carboxymethyl chitosan stabilized Fe3O4 NPs) | 177 | Used for PTT. NPs were found accumulated in the mice tumor region and PTT induced the increase in temperature up to ~ 52 °C | Shen et al. (2013) |