Table 1.

Binding site residues of heliomycin (1) and tetracenomycin D (2) with HDAC1, HDAC2, and HDAC 3

Pdb (Protein)	Binding site residues
5ICN (HDAC1)	Asp 334 (A), Gln 339 (A), Lys 331 (A), Thr 332 (A), Thr 333 (A), Tyr 336 (A), Arg 270 (B), Arg 306 (B), Glu 335 (B) Gly 338 (B), phe 341 (B) and Tyr 336 (B)
4LXZ (HDAC2)	Gln 358 (A), Gly 207 (A), Glu 208 (A), Lys 205 (A), Tyr 206 (A), Asp 337 (A), Arg 41 (B), Hid 38 (B), Glu 340 (B) and Tyr 338 (B)
4A69 (HDAC3)	Arg 345 (A), Gln 71 (B), Gly 99 (B), Glu 102 (B), Leu 70 (B), Phe 101 (B), Pro 75 (B), Pro 98 (B), Ser 74 (B), Thr 76 (B), Val 73 (B), Ala 455 (D), Gly 452 (D), Ser 456 (D) and Val 463 (D)