Table 4.
Suspect product’s active ingredients with the highest proportion of “drug ineffective” reports in FAERS during the study period (top 25)
| Product’s active ingredient | Total FAERS reports | DI reports | % DI |
|---|---|---|---|
| Docosanol | 4282 | 2124 | 49.6 |
| OnabotulinumtoxinA | 13,362 | 5503 | 41.2 |
| Fexofenadine hydrochloride | 9400 | 3462 | 36.8 |
| Bupivacaine hydrochloride | 1085 | 387 | 35.7 |
| Diphenhydramine citrate/ibuprofen | 1326 | 472 | 35.6 |
| Hydroxychloroquine sulfate | 2335 | 829 | 35.5 |
| Oxybutynin | 6573 | 2201 | 33.5 |
| Loratadine | 13,511 | 4397 | 32.5 |
| Suvorexant | 4009 | 1298 | 32.4 |
| Orlistat | 3615 | 1166 | 32.3 |
| Naproxen sodium | 19,349 | 5975 | 30.9 |
| Loratadine/pseudoephedrine sulfate | 4309 | 1250 | 29.0 |
| Dimethicone/loperamide hydrochloride | 2849 | 819 | 28.7 |
| Fesoterodine fumarate | 2186 | 628 | 28.7 |
| Fexofenadine/pseudoephedrine | 1467 | 416 | 28.4 |
| Miconazole nitrate | 1016 | 288 | 28.3 |
| Amphetamine aspartate/amphetamine sulfate/dextroamphetamine saccharate/dextroamphetamine sulfate | 2513 | 705 | 28.1 |
| Acetaminophen/aspirin/caffeine | 2422 | 655 | 27.0 |
| Omeprazole magnesium | 4834 | 1305 | 27.0 |
| Amphotericin B | 1908 | 502 | 26.3 |
| Sildenafil citrate | 15,302 | 3985 | 26.0 |
| Triamcinolone acetonide | 4095 | 1066 | 26.0 |
| Solifenacin succinate | 5688 | 1440 | 25.3 |
| Leflunomide | 3933 | 966 | 24.6 |
| Loperamide hydrochloride | 2788 | 679 | 24.4 |
DI drug ineffective, FAERS FDA Adverse Event Reporting System