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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: J Rheumatol. 2018 Apr 1;45(6):841–850. doi: 10.3899/jrheum.170541

Figure 1. CT scan before and after treatment with Rituximab for BWH Subject 2.

Figure 1

Pre-Rituximab (CT score 125.1) – Axial HRCT images in lung windows (A + B) demonstrate subpleural reticulation, coarse linear bands, groundglass abnormality and patchy consolidation within the lower lobes, lingula and right middle lobe in a predominantly peripheral, subpleural distribution. Affected areas of lung demonstrate traction bronchiectasis and architectural distortion. No honeycombing was present, and lung volumes were mildly reduced. Pattern of interstitial pneumonitis has overlapping features of both non-specific interstitial pneumonia (NSIP) and cryptogenic organizing pneumonia (COP).

>3-years Post-Rituximab (CT score 113.7) – Axial HRCT images (C + D) in lung windows demonstrates definite improvement in bilateral subpleural reticulation, consolidation and architectural distortion. Residual groundglass opacity is present with subpleural sparing, imaging features are consistent with a milder non-specific interstitial pneumonia (NSIP) pattern.