Table 1A.
Demographics at diagnosis by EGFR amplification status across the entire U of C cohort.
| Characteristic | EGFR Amplified | EGFR Non-Amplified | P-Value |
|---|---|---|---|
| Number of patients (%) | 19 (5) | 344 (95) | <2.2×10-16 |
| Median age yrs. (range) | 64 (37–77) | 63 (16–91) | 0.97 |
| Male Sex – no. (%) | 16(84) | 238 (69) | 0.20 |
| Disease Site no. (%) | |||
| Esophagus/GEJ | 12 (63) | 183 (53) | 0.54 |
| Gastric | 7 (37) | 161 (47) | |
| Tumor Grade no. (%) | |||
| Well Differentiated | 0 (0) | 13 (4) | 0.557 |
| Moderately Differentiated | 3 (16) | 89 (26) | |
| Poorly Differentiated | 15(79) | 229 (67) | |
| Unknown | 1 (5) | 13 (4) | |
| Stage at Diagnosis no. (%) | |||
| I | 0 (0) | 35 (10) | 0.11 |
| II | 0 (0) | 43 (13) | |
| III | 4 (21) | 93 (27) | |
| IV | 15(79) | 172 (50) | |
| Unknown | 0 (0) | 1 (0) | |
| HER2 – no. (%) | |||
| Positive | 5 (26) | 81 (24) | 0.91 |
| Negative | 12 (63) | 212 (62) | |
| Equivocal | 0 (0) | 17 (5) | |
| Unknown | 2 (11) | 34 (10) | |
| Race | |||
| Caucasian | 15 (79) | 250 (73) | 0.68 |
| African American | 2 (11) | 58(17) | |
| Asian | 1 (5) | 27 (8) | |
| Hispanic | 1 (5) | 9 (3) |