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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Cancer Res. 2018 Mar 23;78(11):2852–2863. doi: 10.1158/0008-5472.CAN-17-2992

Figure 7. Knockout of MDA-9/Syntenin in PCa inhibits invasion.

Figure 7

A) MDA-9/Syntenin expression in two clones from CRISPR/Cas9-mda-9/syntenin transfected cells. B & C) Expression of igfbp-2 (B) or MMP-2 and MMP-9 mRNA (C) determined in Pool-1 and Pool-2, presented as fold-change vs. control CRISPR/Cas9 transfected cells. D) Expression of indicated mRNA determined in Pool-2. Data presented as fold-change vs. control. E) Cells co-transfected with different expression plasmids. 48 hours later, cells trypsinized and invasion determined. Cells counted using bright field microscopy. Average with S.D. from three independent experiments. “*” represents statistical significance (p<0.05) between indicated groups. F) Hypothetical model of MDA-9/Syntenin-mediated PCa progression.