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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: J Pharm Biomed Anal. 2018 Apr 17;156:97–103. doi: 10.1016/j.jpba.2018.04.018

Fig. 5.

Fig. 5

Prexasertib concentration-time profiles in plasma and tumor extracellular fluid (ECF) for a cerebral microdialysis experiment in one representative mouse bearing a Group 3 MB tumor (closed circles represent observed prexasertib concentrations in plasma, and the solid line represents model predicted concentrations in plasma; closed and open triangles represent recovery corrected prexasertib concentrations in microdialysate above and below the LLOQ, respectively. The dashed line represents model predicted concentrations in microdialysate).