Table 2.
Interval vs. Screen-detected cancers: Associations with clinical characteristics stratified by mammographie density.
| Overall | Non-dense | Dense | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SDC (N=165) |
Interval (N=205) |
Adjusted OR (95% CI)a |
SDC (N=93) |
Interval (N=85) |
Adjusted OR (95% CI)a |
SDC (N=51) |
Interval (N=94) |
Adjusted OR (95% CI)a |
|
| N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | ||||
| Age | |||||||||
| ≥50 | 107 (65) | 115 (56) | 1.0 | 65 (70) | 52 (61) | 1.00 | 30 (59) | 46 (49) | 1.00 |
| ≤50 | 58 (35) | 90 (44) | 1.44 (0.95, 2.20) | 28 (30) | 33 (39) | 1.47 (0.79, 2.74) | 21 (41) | 48 (51) | 1.49 (0.75, 2.97) |
| Tumor size | |||||||||
| ≤ 2 cm | 115 (70) | 103 (52) | 1.0 | 69 (78) | 42 (51) | 1.00 | 33 (66) | 44 (49) | 1.00 |
| ≥ 2 cm | 44 (27) | 94 (46) | 2.33 (1.48, 3.65) | 20 (22) | 41 (49) | 3.22 (1.66, 6.26) | 17 (34) | 45 (51) | 2.00 (0.97, 4.12) |
| Missing | 6 | 8 | 4 | 2 | 1 | 5 | |||
| Nodal status | |||||||||
| Negative | 123 (75) | 127 (62) | 68 (74) | 51 (60) | 1.00 | 38 (75) | 61 (66) | 1.00 | |
| Positive | 41 (25) | 77 (38) | 1.78 (1.13, 2.81) | 24 (26) | 34 (40) | 1.78 (0.94, 3.39) | 13 (25) | 32 (34) | 1.58 (0.73, 3.42) |
| Missing | 1 | 1 | 1 | 0 | 0 | 1 | |||
| Stage | |||||||||
| I/II | 151 (94) | 172 (86) | 85 (94) | 69 (83) | 1.00 | 46 (92) | 81 (89) | 1.00 | |
| III/IV | 9 (6) | 28 (14) | 3.22 (1.43, 7.25) | 5 (6) | 14 (17) | 3.21 (1.09, 9.44) | 4 (8) | 10 (11) | 1.38 (0.40, 4.74) |
| Missing | 5 | 5 | 3 | 2 | 1 | 3 | |||
| ER | |||||||||
| Positive | 112 (71) | 124 (65) | 1.0 | 62 (70) | 48 (61) | 1.00 | 35 (70) | 58 (67) | 1.00 |
| Negative | 46 (29) | 66 (35) | 1.25 (0.79, 1.98) | 26 (30) | 31 (39) | 1.44 (0.75, 2.77) | 15 (30) | 29 (33) | 1.15 (0.54, 2.45) |
| Missing | 7 | 17 | 5 | 6 | 1 | 7 | |||
| PR | |||||||||
| Positive | 94 (61) | 96 (50) | 1.0 | 48 (57) | 35 (45) | 1.00 | 33 (66) | 50 (56) | 1.00 |
| Negative | 60 (39) | 96 (50) | 1.53 (0.99, 2.37) | 36 (43) | 43 (55) | 1.57 (0.84, 2.95) | 17 (34) | 39 (44) | 1.58 (0.76, 3.28) |
| Missing | 11 | 13 | 9 | 7 | 1 | 5 | |||
| HER2 | |||||||||
| Positive | 20 (14) | 23 (12) | 1.0 | 11 (13) | 6 (8) | 1.00 | 6 (13) | 11 (13) | 1.00 |
| Negative | 127 (86) | 162 (88) | 1.24 (0.64, 2.38) | 72 (87) | 69 (92) | 1.84 (0.63, 5.33) | 39 (87) | 75 (87) | 1.32 (0.43, 4.00) |
| Missing | 18 | 20 | 10 | 10 | 6 | 8 | |||
| p53 IHC | |||||||||
| Wild-type | 75 (71) | 78 (67) | 1.0 | 43 (72) | 31 (66) | 1.00 | 23 (70) | 38 (68) | 1.00 |
| Mutant | 30 (29) | 39 (33) | 1.23 (0.69, 2.18) | 17 (28) | 16 (34) | 1.28 (0.55, 2.95) | 10 (30) | 18 (32) | 1.08 (0.41, 2.81) |
| Missing | 60 | 88 | 33 | 38 | 18 | 38 | |||
a
All odds ratios, except those for age, are adjusted for age and menopausal status