Table 1.

Description of Options A, B and B+ and level of evidence

Option	Year of WHO guideline	Regimen for woman		Regimen for infant	GRADE rating
		Treatment (CD4 ≤ 350)	Prophylaxis (CD4 > 350)
Option A	2010a	ART	Pregnancy: AZT Labour: single-dose NVP & AZT/3TC Postpartum: AZT/3TC 7 days	NVP to 1 week after breastfeeding, or 4–6 weeks if not breastfeeding	Strong recommendation Low-quality evidence
Option B	2010 & 2013	ART	Pregnancy and labour: triple ARVs Postpartum until 1 week after breastfeeding	NVP or AZT for 4–6 weeks	2010: Strong recommendation moderate evidence 2013: Conditional recommendation Low-quality evidence
Option B+	2013	ART, regardless of CD4 count		NVP or AZT for 4–6 weeks	Conditional recommendation Low-quality evidence

^aOption B+ included as a research priority in these guidelines