Fig. 1.

Family pedigree of the proband affected by hypogonadism with an LHB mutation. Asterisks indicate the family members who underwent DNA sequencing. The black symbols (IV-2) represent the proband who is a homozygous carriers of the LHB mutation; the open symbols (IV-3) represent the patient’s sister who is normal wild-type sequences of LHB; the dotted-circle symbols (II-2, III-5) indicate the patient’s mother and grandmother who are heterozygous carriers of the LHB mutation