Table 1.
Patient demographics (N = 259) and embryo quality
| Patient demographics | ||
| Age (median, range) | 35 [31–38] | |
| BMI (Median, range) | 25 [22–28] | |
| Ethnicity (N, %) | ||
| White | 157 (60) | |
| Black | 22 (8) | |
| Hispanic | 34 (13) | |
| Asian | 46 (17) | |
| #Embryonic biopsies | 1510 | |
| Embryo quality | mtDNA content (median, range) | |
| All embryos (N = 1510) | (n, %) | 0.000741 [0.0004375–0.00144] |
| *High-quality (grade 1) | 951 (62) | 0.000719 [0.000421–0.0013] |
| Mid—2 | 331 (21) | 0.000736 [0.000409–0.00146] |
| Poor—3 | 228 (15) | 0.000925 [0.000532–0.00275] |
| Euploid embryos | 717 | 0.000637 [0.00037–0.00100] |
| *High-quality (grade 1) | 521 (72) | 0.000624 [0.000363–0.00097] |
| Mid—2 | 140 (20) | 0.000623 [0.00037–0.00112] |
| Poor—3 | 56 (8) | 0.000656 [0.0003915–0.0009345] |
*The Gardner blastocyst grading system assigns three separate quality scores to each blastocyst embryo: (1) Blastocyst development stage—expansion and hatching status (1 = blastocoel cavity less than ½ the volume of the embryo; 2 = blastocoel cavity more than ½ the volume of the embryo; 3 = full blastocyst/cavity completely filling the embryo; 4 = expanded blastocyst/cavity larger than the embryo with thinning of the shell; 5 = hatching out of the cell; 6 = hatched out of the shell. (2) Inner cell mass (ICM) score, or quality (A = numerous and tightly packed; B = several and loosely packed cells; C = few cells). (3) Trophectoderm (TE) score, or quality (A = many tightly packed cells organized into epithelium; B = several cells organized into loose epithelium; C = few cells) grade was defined as follows: 1—High (3 to 6 AA and 4 to 6 AB); 2—Mid (any BB, 1 to 3 AB, and 1 to 2 AA); and 3—Poor (any AC, CA, BC, CB, or CC)