Table 2.

Example cost of control calculation based on the proportion of patients achieving an HbA1c target of < 7.0% without hypoglycemia and with no weight gain

	Once-weekly semaglutide 1.0 mg	Dulaglutide 1.5 mg	Interpretation
Annual drug cost (USD)	8818	8818
Drug cost index	8818/8818 = 1.00	8818/8818 = 1.00	Once-weekly semaglutide 1.0 mg is at price parity with dulaglutide 1.5 mg
Drug efficacy (% of patients with HbA1c < 7%, and no hypoglycemia or weight gain)	74%	58%
Cost per patient achieving control (USD)	8818/74 × 100 = 11,916	8818/58 × 100 = 15,204
Amount spent to achieve target relative to USD 1 spent on once-weekly semaglutide	11,916/11,916 = 1.00	15,204/11,916 = 1.28	For every USD 1 spent on bringing patients to target with once-weekly semaglutide 1.0 mg, USD 1.28 would have to be spent on dulaglutide 1.5 mg