Table 1.
Subject characteristics at baseline and after treatment
| Exenatide | Insulin glargine | Change in value | Estimated difference in value between groups Mean (95% CI) |
P | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Before treatment Mean ± SE |
After treatment Mean ± SE |
P | Before treatment Mean ± SE |
After treatment Mean ± SE |
P | Exenatide Mean (95% CI) |
Insulin glargine Mean (95% CI) |
|||
| Number (n) | 19 | – | – | 20 | – | – | – | – | – | – |
| Sex (male/female) | 12/7 | – | – | 10/10 | – | – | – | – | – | – |
| Age | 46.74 ± 2.31 | – | – | 49.45 ± 2.17 | – | – | – | – | – | – |
| Diabetic duration | 6.37 ± 0.99 | – | – | 4.35 ± 0.68 | – | – | – | – | – | – |
| Weight (kg) | 80.36 ± 2.35 | 76.85 ± 2.36 | < 0.001 | 74.75 ± 1.95 | 75.20 ± 1.98 | 0.263 | − 3.51 (− 5.09 to − 1.93) | 0.45 (− 0.37 to 1.27) | − 3.96 (− 5.65 to − 2.27) | < 0.001 |
| BMI (kg/m2) | 28.03 ± 0.50 | 26.81 ± 0.51 | < 0.001 | 27.08 ± 0.52 | 27.24 ± 0.55 | 0.258 | − 1.22 (− 1.78 to − 0.65) | 0.17 (− 0.13 to 0.47) | − 1.38 (− 1.99 to − 0.77) | < 0.001 |
| Waist circumference (cm) | 96.74 ± 1.50 | 93.71 ± 1.59 | 0.012 | 93.70 ± 1.52 | 93.30 ± 1.48 | 0.366 | − 3.03 (− 5.30 to − 0.75) | − 0.40 (− 1.30 to 0.50) | − 2.62 (− 5.03 to − 0.22) | 0.061 |
| ALT (U/L) | 31.79 ± 4.33 | 31.56 ± 3.96 | 0.949 | 36.46 ± 4.82 | 28.83 ± 3.81 | 0.027 | − 0.23 (− 7.75 to 7.28) | − 7.63 (− 14.27 to − 0.99) | 7.39 (− 2.27 to 17.05) | 0.183 |
| AST (U/L) | 22.28 ± 2.13 | 21.97 ± 2.18 | 0.855 | 24.78 ± 2.15 | 22.39 ± 1.92 | 0.103 | − 0.32 (− 3.92 to 3.29) | − 2.39 (− 5.31 to 0.53) | 2.07 (− 2.37 to 6.51) | 0.522 |
| TG (mmol/L) | 1.75 ± 0.17 | 1.61 ± 0.23 | 0.286 | 1.70 ± 0.17 | 1.49 ± 0.19 | 0.295 | − 0.15 (− 0.42 to 0.13) | − 0.21 (− 0.63 to 0.20) | 0.07 (− 0.42 to 0.55) | 0.744 |
| TC (mmol/L) | 4.55 ± 0.31 | 4.04 ± 0.28 | 0.019 | 4.45 ± 0.23 | 4.30 ± 0.15 | 0.557 | − 0.51 (− 0.93 to − 0.10) | − 0.14 (− 0.64 to 0.35) | − 0.37 (− 1.00 to 0.25) | 0.183 |
| HDL (mmol/L) | 1.04 ± 0.05 | 1.00 ± 0.06 | 0.324 | 1.03 ± 0.05 | 1.11 ± 0.07 | 0.147 | − 0.04 (− 0.11 to 0.04) | 0.09 (− 0.03 to 0.21) | − 0.12 (− 0.26 to 0.01) | 0.083 |
| LDL (mmol/L) | 2.42 ± 0.21 | 2.07 ± 0.20 | 0.010 | 2.36 ± 0.17 | 2.28 ± 0.11 | 0.617 | − 0.35 (− 0.60 to − 0.10) | − 0.09 (− 0.44 to 0.27) | − 0.26 (− 0.69 to 0.16) | 0.153 |
P values of < 0.05 were considered to indicate significant differences between the groups
BMI body mass index, ALT alanine aminotransferase, AST aspartate aminotransferase, TG triglyceride, TC total cholesterol, LDL low-density lipoprotein cholesterol, HDL high-density lipoprotein cholesterol