(A) Predicted monotonic increase in closure points for both models due to increasing static external pressure. The DM shows great quantitative and qualitative agreement to the full MoC model for this static case, with a 2 to 5% difference, as well as having absolute differences in the range 0–1.2. (B and C) Comparison of the sum of the attached myosin populations for both models at P0 = 5 cmH2O and P0 = 25 cmH2O, respectively. These distribution plots were taken at the first instant after the closure threshold, , was passed. At low external pressure, the moment matching of the DM is a good approximation to the exact distribution of the MoC (B), but it deviates as the external pressure is increased, as seen in (C), which leads to qualitative differences in .