Figure 4.

Effect of ECM-mediated lateral stabiization on ECM degradation and invadopodia speed. (A) To model the effect of cell-ECM adhesion on invadopodia penetration, the number of ECM sites surrounding the invadopodia structure was quantified and the probability of invadopodia penetration was made to depend on the fraction of lateral invadopodia surface covered by ECM sites. (B) Probability of penetration $\left(p_{pen}\right)$ for varying extents of lateral stabilization. (C and D) Dependence of ECM degradation (C) and invadopodia speed (D) on ECM density, in the presence of cell-ECM adhesion-mediated feedback. At least 50 simulations per condition were performed. Error bars are ± standard deviation. To see this figure in color, go online.